Techcrunch has a great Paul Graham interview on startups. Graham: "make something people want". Good advice :-)
I have been more than a little frustrated this year: I have my own startup idea that I am keen to pursue but I have had both interesting and educational consulting gigs and it is difficult, at least for me, to walk away from good work.
Politically and socially, I love the idea of small agile groups of people taking market share away from large corporations - turn the economy of scale upside down by leveraging agility.